Loading... B6.Cg-Ins2Akita Ldlrtm1Her/J Mice homozygous for the Akita spontaneous mutation die postnatally, typically by 12 weeks of age. Independently, heterozygous Akita mutant mice are a model of insulin dependent diabetes mellitus (IDDM) with severe hyperglycemia (see the datasheet for Stock No. 003548 for additional information). LDLR-null homozygotes have elevated serum cholesterol levels (200-400 mg/dl) which can escalate to very high levels (> 2000 mg/dl) when the mice are fed a high fat diet. LDLR-deficient mice also are predisposed to develop atherosclerosis. These double mutant mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, hypercholesterolemia, and diabetes-related macrovascular complications. Phenotyped For Other Resources Metabolic Cardiovascular Nephropathy Neuropathy Retinopathy Uropathy Histology Images Reagents Publications Coming Soon Coming Soon Coming Soon Coming Soon Coming Soon Coming Soon Primary Data Primary Data, Continued Primary Data, Kidney Primary Data, CV plasma glucose (mg/dL) Series Sex N Avg SD B6.Cg-Ins2Akita Ldlrtm1Her/J Both 50 279.78 143.00   Male 50 279.78 143.00 BothFemaleMale Investigator Resources Name Models Grant Abstract Annual Report Publications Presentations Leiter, Ed View Models Not Available Not Available View Publications View Presentations