AMDCC :: Publication

Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK.

Authors	Ix JH, Sharma K
Submitted By	Kumar Sharma on 3/24/2010
Status	Published
Journal	Journal of the American Society of Nephrology : JASN
Year	2010
Volume : Pages	21(3) : 406 - 412
PubMed Reference	20150538
Abstract	Obesity is a risk factor for chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD). Recent studies identify mechanisms common to both diseases linked through an interorgan communication orchestrated by fetuin-A and adiponectin. In liver and kidney, the energy sensor 5'-AMP activated protein kinase (AMPK) is pivotal to directing podocytes and hepatocytes to compensatory and potentially deleterious pathways, leading to inflammatory and profibrotic cascades culminating in end-organ damage. Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity.

Investigators with authorship

Name	Institution
Kumar Sharma	University of California San Diego

Complications
All ComplicationsBioinformatics CardiomyopathyCardiovascular NephropathyNeuropathy RetinopathyUropathy


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