AMDCC :: Publication

Mouse Models of Diabetic Nephropathy:A Midstream Analysis from the Animal Models of Diabetic Complications Consortium

Authors	Frank C. Brosius IIIa, Charles E. Alpersb, Erwin P. Bottingerc, Matthew D. Breyerd, ThomasM. Coffmane, Susan B. Gurleye, Raymond C. Harrisf, Masao Kakokig, Matthias Kretzler, Edward H. Leiterh, Moshe Levii, Richard A. McIndoej, Kumar Sharmak, Oliver Smithiesg, Katalin Susztakl, Nobuyuki Takahashig, Takamune Takahashif
Submitted By	Frank Brosius on 7/6/2009
Status	Published
Journal	Journal of the American Society of Nephrology : JASN
Year	2009
Volume : Pages	20(12) : 2503 - 2512
PubMed Reference	19729434
Abstract	Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of reliable animal models that mimic human disease has delayed the identification of specific factors that cause or predict diabetic nephropathy. The Animal Models of Diabetic Complications Consortium (AMDCC) was created in 2001 by the National Institutes of Health to develop and characterize models of diabetic nephropathy and other complications. This interim report and our online supplement detail the progress made toward that goal, specifically in the development and testing of murine models. Updates are provided on validation criteria for early and advanced diabetic nephropathy, phenotyping methods, the effect of background strain on nephropathy, current best models of diabetic nephropathy, negative models, and views of future directions. AMDCC investigators and other investigators in the field have yet to validate a complete murine model of human diabetic kidney disease. Nonetheless, the critical analysis of existing murine models substantially enhances our understanding of this disease process.

Investigators with authorship

Name	Institution
Erwin Bottinger	Mount Sinai School of Medicine
Matthew Breyer	Vanderbilt University
Frank Brosius	University of Michigan
Thomas Coffman	Duke University Medical Center
Raymond Harris	Vanderbilt University
Matthias Kretzler	University of Michigan
Ed Leiter	Jackson Laboratory
Moshe Levi	University of Colorado
Richard McIndoe	Medical College Of Georgia
Kumar Sharma	University of California San Diego
Oliver Smithies	University of North Carolina
Takamune Takahashi	Vanderbilt University

Complications
All ComplicationsBioinformatics CardiomyopathyCardiovascular NephropathyNeuropathy RetinopathyUropathy


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