Pilot and Feasibility Program
About the AMDCC:
The AMDCC is an interdisciplinary consortium developing new animal models of diabetic complications.
The consortium consists of 13 sites studying a range of diabetic complications, including diabetic
nephropathy, uropathy, neuropathy, and cardiovascular disease.
Additional goals of the AMDCC are to define criteria needed to assess outcomes in animals for relevance to the human condition, to test candidate genes emerging from human genetic studies, and to facilitate the
exchange of reagents and expertise between the consortium and the scientific community.
To facilitate its mission, the AMDCC partners with the Type 1 Diabetes Resource at Jackson Laboratories
(www.type1diabetes.jax.org) and the NIH Mouse Metabolic Phenotyping Centers (www.mmpc.org).
AMDCC Pilot & Feasibility Opportunities in 2010
The AMDCC is currently soliciting P&F proposals that advance the mission of the consortium.
Current areas of interest include, but are not limited to:
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Generation and characterization of stem cell populations, including pluripotent or tissue-specific stem cells, or human and mouse iPS, to support preclinical studies of therapeutic efficacy in animal models of diabetic complications;
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Examination of regenerative and repair functions of endogenous cell populations in animal models of diabetes and its complications;
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Evaluation of the impact of diabetes and its complications on stem cell production, function and recruitment to cellular niches at sites of end-organ injury;
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Development of mouse models with humanized cell populations or organ
systems suitable for use in complications research (eg, mice with human
endothelium, skin, cardiac, kidney, nervous or urologic tissue);
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Production and validation of immunodeficient mouse models to serve as recipients
for transfer of human cell populations to assay or impact diabetic complications;
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Validation of phenotyping assays to measure efficacy of cell-based therapies for diabetic complications.
Budget requests should be commensurate with project needs over a one year project period.
While average AMDCC P&F awards are $60,000 Total Costs for one year, well justified
requests for support of up to $100,000 Total Costs per year will be considered.
In 2010, current members of the AMDCC are NOT eligible to serve as P&F project directors or principal
investigators. However, in certain circumstances AMDCC members may participate as collaborators,
consultants or key personnel on proposals submitted by external investigators.
International institutions and organizations are eligible for support.
Applications are due Monday, May 03, 2010 for June 2010 start dates.
For instructions on how to submit a Pilot & Feasibility Funding Program Application to the AMDCC
web portal please click the following link:
AMDCC Funding Program Application Submission Basic Training (PDF)
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Applicants may request up to $60,000 (direct + indirect costs) Total Costs for one year, well justified requests for support of up to $100,000.
A narrative justification should be provided only for any major
equipment (cost greater than $5,000) deemed to be necessary for the proposed project. The number of awards will depend upon the number, quality, duration, and cost
of the applications received.
Awards will be made as subcontracts from the AMDCC Coordinating and Bioinformatics Unit (CBU) at the Medical College of Georgia and not directly by the NIH.
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Each submitted proposal will be assigned to three reviewers who are either members of the AMDCC External Advisory Board or external
scientists with expertise in the area of a proposal. Reviewers may be at an institution affiliated with the AMDCC, but should not
serve as a member of the AMDCC steering committee (please see www.amdcc.org). Scientists from institutions submitting a proposal
are in conflict and excluded from review. Final funding decisions will be made by the NIH.
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| FEB 1, 2010 |
RFA for AMDCC Pilot Projects posted on NIH website, AMDCC website, MMPC websites, and notification of the postings
is sent to all US academic and research institutions. |
| MAY 1, 2010 |
Grants Submitted to CBU (Dr. Richard McIndoe, CA 4127, Medical College of Georgia, Augusta, Georgia, 30912) |
| JUNE 1, 2010 |
Start date for AMDCC Pilot Project Funding |
The application is the standard PHS 398 form including face, abstract, detailed budget,
biographical and other support pages (up to 4 pages), and research plan. The research plan
should include the following sections:
- Specific Aims,
- Background and Significance,
- Preliminary Studies,
- Research Design and Methods,
- Literature Cited,
- Vertebrate Animals
- Sharing Plan
(Sections A-D are limited to 5 PAGES). The eligibility requirements for the Pilot
and Feasibility awards are limited to full time faculty that meet the criteria described
below.
NOTE: Applicants should submit one (1) paper copy to the AMDCC CBU at the address listed below,
plus
submit an electronic version of the application via the AMDCC website (PDF format only please).
Eligible Organizations:
Public/State Controlled Institution of Higher Education; Private Institution of Higher Education;
Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled
Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Nonprofit with
501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS
Status (Other than Institution of Higher Education); Non-domestic (non-U.S.) Entity; Small Business;
For-Profit Organization (Other than Small Business); State Government; Regional Organization; U.S.
Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native
American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated
Organization; Eligible agencies of the Federal government; Faith-based or community based organizations.
Eligible Project Directors/Principal Investigators:
Current members of the AMDCC (please see www.amdcc.org for full details) are not eligible to serve as project director, principle investigator,
or funded key personnel. Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work
with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals
with disabilities are always encouraged to apply for NIH support. Young investigators are encouraged to apply.funded key personnel.
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Please note that projects devoted to the development of new techniques and tests for the metabolic characterization of
mice are NOT responsive to this announcement and are better suited for the MMPC Pilot and Feasibility Grant Program
(please see www.mmpc.org for more details). In brief, this program supports applications to:
- Develop new technologies or miniaturization of existing technologies for use in mice,
- Develop applications of existing technologies for use in mice,
- Provide new tests to meet identifiable, outstanding needs necessary to phenotype mouse models of metabolic disease, and
- Establish new types of mathematical models, informatics, databases or products that augment the mission of the center.
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| A summary of progress of funded projects is due two months following the completion
of the funding period (July 31 of the year following the start of funding). |
Richard McIndoe, Ph.D. (Coordinator)
Coordinating and Bioinformatics Unit
Medical College of Georgia
Center for Biotechnology and Genomic Medicine
1120 15th Street, CA4124
Augusta, GA 30912-4810
Phone: 706-721-3542
Fax: 706-721-3688
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