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129S/SvEv 129S6/SvEv 129X1/SvJ A/J B6.129S7-Ldlr<tm1Her> /J B6.Cg(SJL)-TgN(Nes-cre)1Kln B6;129S7-Fyn<tm1Sor> B6SJL-TgN(Myl2SLC2A1)2Mue BALB/cJ BKS.Cq-m Lepr<db>/+ + C57BL/6 C57BL/6-Ipf1 <+/-> C57BL/6J C57BL/6J-Ins2<Akita> C57BL/6J-Lepr<db> C57BL/6J-Slc2a4<tm1Cha> C57BL/6J-Tg(SLC2A4) C57BLKS/J C57BLKS/J-Lepr<db/db> C57BLKS/J-Lepr<db/m> CAST/Ei CD1 DBA/2J FH/IS FVB-Ldlr<-/-> FVB.BKS(D)-+/?/ChuaJ FVB.BKS(D)-Lepr <db>/ChuaJ FVB/NJ KK/HlJ MRL/MpJ NON/LtJ Swiss Webster  Sex M+F M F

[Leiter] Baseline Metabolic Phenotyping for AMDCC Mouse Strains

Abel, E. Dale Bottinger, Erwin Breyer, Matthew Brosius, Frank Charron, Maureen Coffman, Thomas Daneshgari, Firouz Dansky, Hayes Feldman, Eva Fisher, Edward Goldberg, Ira Harris, Raymond Heilig, Charles Hunter-Schaedle, Kim Kretzler, Matthias Leiter, Ed Levi, Moshe Maeda, Nobuyo McIndoe, Richard Sharma, Kumar Smithies, Oliver Takahashi, Takamune

alanine amino transferase alkaline phosphatase AMPK Activity aortic arch (cross section) lesion area Aortic Atherosclerosis Morphometry - Intimal Area Aortic Atherosclerosis Morphometry - Intimal Area as % Medial Area Aortic Atherosclerosis Morphometry - Medial Area aortic flow 00 minutes aortic flow 20 minutes aortic flow 40 minutes aortic flow 60 minutes aortic sinus (cross section) lesion area aortic surface area section A aortic surface area section B aortic surface area section C arterial blood glucose arterial clamp plasma NEFA arterial clamp plasma non-esterified fatty acids arterial hematocrit arterial insulin arterial NEFA arterial plasma corticosterone arterial plasma epinephrine arterial plasma glucagon arterial plasma insulin arterial plasma NEFA arterial plasma norepinephrine aspartate amino transferase average clamp glucose average glucose infusion rate basal glucose basal HGP basal insulin blood glucose blood insulin blood pressure: developed blood pressure: developed 00 minutes blood pressure: developed 20 minutes blood pressure: developed 40 minutes blood pressure: developed 60 minutes blood pressure: diastole blood pressure: diastole 00 minutes blood pressure: diastole 20 minutes blood pressure: diastole 40 minutes blood pressure: diastole 60 minutes blood pressure: systole blood pressure: systole 00 minutes blood pressure: systole 20 minutes blood pressure: systole 40 minutes blood pressure: systole 60 minutes blood urea nitrogen body length A/N (rodent) body weight (pig) body weight (rodent) bone area bone mineral content bone mineral density brain glucose metabolic index Brain Kg brain weight (rodent) BUN/Creatinine Ratio C16:0 CoA ester C16:1 CoA ester C18:0 CoA ester C18:1 CoA ester C18:2 CoA ester C18:3 CoA ester cardiac efficiency cardiac efficiency 00 minutes cardiac efficiency 20 minutes cardiac efficiency 40 minutes cardiac efficiency 60 minutes cardiac output cardiac power 00 minutes cardiac power 20 minutes cardiac power 40 minutes cardiac power 60 minutes Circumflex Coronary Artery Atherosclerosis Morphometry - Intimal Area Circumflex Coronary Artery Atherosclerosis Morphometry - Intimal Area as % Medial Area Circumflex Coronary Artery Atherosclerosis Morphometry - Medial Area Circumflex Coronary Artery Atherosclerosis Morphometry - Percent Stenosis Clamp Glucose Clamp HGP coronary flow coronary flow 00 minutes coronary flow 20 minutes coronary flow 40 minutes coronary flow 60 minutes coronary flow/heart weight diaphragm glucose metabolic index diaphragm Kg dry heart weight EE 30 min exercise EE basal EE exhaustion EE max ejection fraction en face abdominal aorta lesion area en face abdominal aorta lesion area % En Face Abdominal Aorta Lesion Area (Pig) En Face Abdominal Aorta Lesion Percent (Pig) en face abdominal aorta total area En Face Abdominal Aorta Total Area (Pig) en face aortic arch lesion area en face aortic arch lesion area % en face aortic arch total area en face thoracic aorta lesion area en face thoracic aorta lesion area % en face thoracic aorta total area endo RA endurance time experimental insulin fasting glucose fasting insulin fat body mass fatty streaks/total lesion ratio food intake fractional shortening free water Frequently sampled intravenous glucose tolerance test - Glucose Conc. Frequently sampled intravenous glucose tolerance test - Insulin Conc. gastrocnemius glucose metabolic index gastrocnemius glycogen gastrocnemius Kg GFR inulin clearance (FITC-inulin IV bolus injection) glucose infusion rate glucose oxidation 00-20 minutes glucose oxidation 20-40 minutes glucose oxidation 40-60 minutes Glucose Uptake glutamine dehydrogenase glycogen synthesis glycolysis glycolysis 00-20 minutes glycolysis 20-40 minutes glycolysis 40-60 minutes glycosylated hemoglobin HCT heart glucose metabolic index heart glycogen heart Kg heart rate heart weight:tibia length ratio heart:body weight ratio hematocrit hemoglobin high-density lipoprotein cholesterol insulin dose interventricular septal diameter diastole intraperitoneal glucose tolerance test: 000min (baseline) intraperitoneal glucose tolerance test: 005min post-injection intraperitoneal glucose tolerance test: 015min post-injection intraperitoneal glucose tolerance test: 030min post-injection intraperitoneal glucose tolerance test: 060min post-injection intraperitoneal glucose tolerance test: 120min post-injection KG brain KG dia KG gas KG heart KG sol KG vas kidney weight:tibia length ratio lean body mass Left Anterior Descending Coronary Artery Morphometry - Intimal Area Left Anterior Descending Coronary Artery Morphometry - Intimal Area as % Medial Area Left Anterior Descending Coronary Artery Morphometry - Medial Area Left Anterior Descending Coronary Artery Morphometry - Percent Stenosis left kidney weight (mouse) Left Ventricle End Diastolic Pressure left ventricular diameter diastolic left ventricular diameter systolic left ventricular ejection fraction left ventricular mass left ventricular outflow index left ventricular posterior wall diameter in diastole left ventricular systolic pressure leptin lesion area aortic section A lesion area aortic section C Lesion Complexity Index lesion surface area section b liver weight liver weight:tibia length ratio liver:body weight ratio low-density lipoprotein cholesterol LV internal diameter end-diastole LV internal diameter end-systole LV mass LV posterior wall thickness end-diastole LV posterior wall thickness end-systole LV septal wall thickness end-diastole LV septal wall thickness end-systole mean brachiocephalic artery lesion size mean cell volume mean corpuscular hemoglobin mean corpuscular hemoglobin concentration mean platelet volume mesangial index myocardial oxygen consumption myocardial oxygen consumption 00 minutes myocardial oxygen consumption 20 minutes myocardial oxygen consumption 40 minutes myocardial oxygen consumption 60 minutes negative pressure change/time non-esterified free fatty acids oral glucose tolerance osmolality (Calculated) palmitate oxidation 00-20 minutes palmitate oxidation 20-40 minutes palmitate oxidation 40-60 minutes percent body fat (rodent) percent of aortic surface covered by lesion plantar hind paw analgesia test plasma free fatty acids plasma glucose plasma hepatic lipase activity plasma insulin plasma triglycerides plasma unesterified cholesterol platelet count positive pressure change/time Post-op body weight (Rodent) Pre-op body weight (Rodent) pressure change/time maximum pressure change/time minimum pulse RA Rat Pressure Product (Developed Pressure time HR) Rd red blood cell count Respiratory Control RG brain RG dia RG gas RG heart RG sol RG vas Right Coronary Artery Atherosclerosis Morphometry - Intimal Area Right Coronary Artery Atherosclerosis Morphometry - Intimal Area as % Medial Area Right Coronary Artery Atherosclerosis Morphometry - Medial Area Right Coronary Artery Atherosclerosis Morphometry - Percent Stenosis right kidney weight (mouse) RR systolic sciatic motor conduction velocity serium insulin: 000min (baseline) serium insulin: 030min (post injection) serum albumin serum albumin to globulin ratio serum amylase serum calcium serum chloride serum creatine phosphokinase serum creatinine serum gamma glutamyl transpeptidase serum globulin serum lactic dehydrogenase serum lipase serum magnesium serum phosphorus serum potassium serum sodium serum total bilirubin serum total protein serum triglycerides soleus glucose metabolic index soleus Kg spleen weight spleen weight:tibia length ratio spleen:body weight ratio subcutaneous fat pad weight superficial vastus lateralis glycogen SVL glucose metabolic index SVL Kg tail flick analgesia test tail motor latency tail sensory conduction velocity tibia length (mouse) total albumin excretion total aortic surface area total body weight total cholesterol total creatinine excretion total kidney weight (mouse) total kidney:body weight ratio total lesion area on the aorta triglycerides urine albumin (Exocell Albulwell M ELISA) urine albumin/urine creatinine ratio urine creatinine (Exocell Picric Acid method) VCO2 30 Min Exercise VCO2 basal VCO2 exhaustion VCO2 max very-low density lipoprotein cholesterol VO2 30 min exercise VO2 basal VO2 Exhaustion VO2 max wet heart weight (mouse) white blood cell count whole body glucose turnover whole body glycogen/lipid synthesis whole body glycolysis Work Duration WR max

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age at start of diet (month) age at start of diet (week) Angiotensin II dose (milligrams per kilogram per minute) calcium concentration (millimole) Duration of Banding (week) duration of treatment (day) fast duration (hour) Fasted Fasted 2 (hour) Fun Stuff glucose concentration (millimole) glucose dose (milligrams per kilogram) glucose infusion rate (milligrams per kilogram per minute) glutamate concentration (millimole) Insulin insulin concentration (nanomole) insulin dose (miliUnits per kilogram) insulin dose 2 (milligrams per kilogram per minute) IP glucose dose (milligrams per kilogram) IP STZ dosage plan IP STZ dose (milligrams per kilogram) isoproterenol treatment/delivery (milligrams per kilogram per minute) malate concentration (millimole) monoclonal antibody antagonists (human) monoclonal antibody antagonists (human)' mouse diet mouse diet palmitate concentration (millimole) palmitoyl carnitine concentration (millimole) pig diet pyruvate concentration (millimole) Surgery Performed time sample taken (minute) time since baseline (day) time since baseline (minute) time since baseline (week) time since start of diet (week) time since start of study (month) time since surgery (day) time since surgery 2 (day) time since Type 1 Diabetes onset (day) time since Type 1 Diabetes onset (week) tissue section number for assesment Tissue Source total time on diet (month) total time on diet (week) treatment wheel running (day) = <> > >= < <=