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Welcome to AMDCC

The AMDCC is an interdisciplinary consortium designed to develop new animal models that closely mimic the human complications of diabetes for the purpose of studying disease pathogenesis, prevention and treatment. The consortium consists of thirteen "pathobiology sites" that study complications such as diabetic nephropathy, uropathy, neuropathy, cardiomyopathy and vascular disease.

Additional goals of the AMDCC are to define criteria to validate each diabetic complications for its similarity to the human disease, test the role of candidate genes that emerge from human genetic studies, and facilitate the exchange of models, tissues, reagents, and expertise between members of the consortium and the greater scientific community.

To ensure that all models generated by the AMDCC are phenotyped for a full duration of diabetes and across all relevant complications, the consortium has formed a close partnership with the Jackson Laboratories and the NIDDK-funded Mouse Metabolic Phenotyping Centers.

What's NEW at AMDCC...


	Mouse Metabolic Phenotyping Centers Consortium (U24) (RFA-DK-10-006) National Institute of Diabetes and Digestive and Kidney Diseases National Heart, Lung, and Blood Institute. Application Receipt Date(s): November 17, 2010


	Coordinating and Bioinformatics Unit for the Mouse Metabolic Phenotyping Centers and the Diabetic Complications Consortium (U24) (RFA-DK-10-007) National Institute of Diabetes and Digestive and Kidney Diseases Application Receipt Date(s): November 18, 2010


	Knockout Mouse Project Repository (KOMP) The KOMP Repository (www.komp.org) is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. At the KOMP Repository at UC Davis and CHORI, you can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.


	Tracers in Metabolic Research Course (MMPC) A week-long course in the theory and practice of isotopic tracers (stable and radioactive) for the study of metabolism in man and animals using mass spectrometry and NMR.


	An Organ Systems Approach to Experimental Targeting of the Metabolic Syndrome (MMPC) The course will be an intensive two week experience for 20 students. The objective of the course is to give students the tools needed to assess whether an experimental intervention (pharmacologic, genetic, dietary, or environmental) alters macronutrient metabolism, energy balance, cardiovascular homeostasis or animal behavior. To accomplish this, we will use a combination of lectures, hands on laboratories, demonstrations and data problem sessions.


	Translational Research in Metabolic Syndrome and Cardiovascular Disease Translational Research in Metabolic Syndrome and Cardiovascular Disease: Swine vs. Mouse Models (Sponsored by the APS Cardiovascular Section)


	AMDCC Pilot & Feasibility Program AMDCC is currently soliciting Pilot and Feasibility proposals that advance the mission of the AMDCC. Click here to view more information.


	NEW Frequently Asked Questions and Tutorial Section! We have recently added a Tutorial and Frequently Asked Questions (FAQ) sections to the website. The tutorials are movies describing how to do the most common tasks on the website (requires FLASH). The FAQ section provides basic information and is updated periodically. Just go to Main => Tutorial/FAQ or click here.


	Plot or Chart Your Analysis. When performing a statistical analysis, users now have the ability to chart the strain combinations on-the-fly directly from the analysis results page. This capability has been implemented for both the basic statistics and ANOVA interfaces. Users can plot column, line or XY charts for two or more filtered strains. Just go to Data Analysis => Statistical Exploration or click here.


	Analyze the Strains from Chart Exploration When performing chart exploration, users now have the ability to perform on-the-fly statistical exploration for the strains plotted. This capability has been implemented for both the basic statistics and ANOVA interfaces. Just go to Data Analysis => Chart Exploration or click here.


	AMDCC Presentations Available The presentations for the semi-annual meetings are now available to the public. These include the invited speakers when available. All presentations are in PDF format to minimize spacre requirements. Just go to About AMDCC => Presentations or click here.


	AMDCC Annual Reports are now available. All Investigators in the AMDCC must provide an annual report to the NIH. These reports are now available to the public. All reports are in PDF format to minimize space requirements. Just go to About AMDCC => Annual Reports or click here.

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FEATURED PUBLICATIONS

Bioinformatics

ParaSAM: A parallelized version of the significance analysis of microarrays algorithm.

Uropathy

Animal models of diabetic uropathy.

Nephropathy

Mouse Models of Diabetic Nephropathy:A Midstream Analysis from the Animal Models of Diabetic Complications Consortium

Retinopathy

Retinal Ion Regulation in a Mouse Model of Diabetic Retinopathy: Natural History and the Effect of Cu/Zn Superoxide Dismutase Overexpression

Cardiovascular

Recipes for Creating Animal Models of Diabetic Cardiovascular Disease

UPCOMING MEETINGS

1st International Diabetes and Obesity Forum


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