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AMDCC STATS
In Progress14
Public62
Total76
Total21
 | Models
In Progress82
Public2
Total84
Total54
In Press / Published41
 | Strains
Breeding Complete12
Breeding Ongoing27
Characterizing Multiple Lines3
Embryonic Rederivation1
Not Applicable685
Not Specified / Other1
Phenotyping Complete5
Phenotyping Final2
Phenotyping Ongoing31
Total767
Welcome to AMDCC

The Animal Models of Diabetic Complications Consortium (AMDCC) brings together a number of projects representing a diverse set of disciplines and technologies with the goal of improving or creating animal models of human diabetes complications.

The primary goal for this consortium is the creation of the animal models to study diabetes complication pathologies with an emphasis on the etiology, prevention and treatment of the disease. The secondary goal is to use these animal models to elucidate the role of specific genes or chromosomal regions in the pathogenesis of these complications.

The consortium consists of eight Mouse Engineering and Phenotyping units from different institutions and one Coordinating and Bioinformatics unit. Members of the AMDCC come from a diverse set of backgrounds with expertise in mouse genetic engineering technologies, organ pathologies, genomic technologies and diabetic complications.

Investigators focus their research efforts on a number of diabetic complications involving different organ systems and biochemical pathways. These complications include diabetic kidney disease, vascular disease, retinopathy, neuropathy and diabetic cardiomyopathy.

This complex research initiative will provide a valuable resource to the scientific community and will require the coordinated effort between the members of the consortium.

CONGRATULATIONS to OLIVER SMITHIES

The Nobel Assembly at Karolinska Institutet has today decided to award
The Nobel Prize in Physiology or Medicine for 2007 jointly to

Mario R. Capecchi, Martin J. Evans and Oliver Smithies

for their discoveries of "principles for introducing specific gene modifications in mice by the use of embryonic stem cells"

Summary


This year's Nobel Laureates have made a series of ground-breaking discoveries concerning embryonic stem cells and DNA recombination in mammals. Their discoveries led to the creation of an immensely powerful technology referred to as gene targeting in mice. It is now being applied to virtually all areas of biomedicine – from basic research to the development of new therapies.


The AMDCC would like to congratulate Dr. Smithies for this well deserved honor.

To see the entire press release click http://nobelprize.org/nobel_prizes/medicine/laureates/2007/press.html


NIDDK Request for Information:

Agents to be tested for Preclinical Efficacy in Prevention or Reversal of Diabetic Complications in Rodent Models.

The NIDDK has recently awarded a contract establishing a rodent model testing program to assist in development of therapeutic interventions for the prevention or reversal of complications of type 1 diabetes. The contract provides independent investigators with access to the resources and expertise required to evaluate agents for preclinical therapeutic efficacy in rodent models. NIDDK invites scientists to submit information describing promising new therapeutics or intervention strategies that may require further testing in rodent models prior to moving forward for evaluation in patients with diabetic complications.


Visit Type 1 Diabetes Preclinical Testing Program (T1D-PTP) page or NIH Notice page for more information.

Click here for Tutorials and Frequently Asked Questions (FAQ)


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PUBLICATIONS
ParaKMeans: Implementation of a Parallelized K-means algorithm Suitable for General Laboratory Use.
Adipokines and Albuminuria: A Direct Communication between Adiponectin and Podocytes
Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in Diabetes
Diabetic Cardiomyopathy Revisited
SOD2 Protects Neurons from Injury in Cell Culture and Animal Models of Diabetic Neuropathy
Decorin Deficiency Enhances Progressive Nephropathy in Diabetic Mice
Endothelial Nitric Oxide Synthase Deficiency Produces Accelerated Nephropathy in Diabetic Mice
Diabetic Vascular Disease. An Experimental Objective
Alterations in neurogenically mediated contractile responses of urinary bladder in rats with diabetes
Accelerated Diabetic Nephropathy in Mice Lacking the Peroxisome Proliferator-Activated Receptor-alpha
More Publications
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